![]() These alterations include the menstrual synchrony effect first documented by McClintock (1971) in an all-female living group and later replicated by others in coeducational facilities (Graham and McGrew, 1980 Quadagno et al., 1981). (1996) noted several studies in humans suggesting that axillary odors and secretions from both males and females are a source of chemical signals containing physiologically active components capable of altering the female menstrual cycle. These results suggested a remarkable similarity between human axillary secretions and nonhuman mammalian odor sources, where lipocalins have been shown to carry the odoriferous signals used in pheromonal communication. In situ hybridization of an oligonucleotide probe against apoD mRNA with axillary tissue demonstrated that the message for synthesis of this protein is specific to the apocrine glands. (1996) that there are different sites of expression for the 2 glycoproteins. The pattern of glycosylation for axillary apoD differs from that reported for plasma apoD, suggesting to Zeng et al. The authors used mass spectrometry to determine the amino acid sequence and glycosylation pattern of ASOB2. (1996) identified apoD as apocrine secretion odor-binding protein-2 (ASOB2), 1 of 2 glycoproteins that bind E-3-methyl-2-hexenoic acid (E-3M2H), the most abundant axillary odor component in human males. (1989) demonstrated for the first time polymorphism of apolipoprotein D by an isoelectric focusing-immunoblotting technique. (1987) described multiple RFLPs at the APOD locus. ![]() ApoD mRNA has been detected in many tissues. This structural similarity may indicate some functional homology of these proteins. The 169-amino acid protein bore little similarity to other lipoprotein sequences but had a high degree of homology to plasma retinol-binding protein (180250, 180260, 180280, 180290), a member of the alpha(2mu)-globulin superfamily. (1986) reported the amino acid sequence of apoD based on the nucleotide sequence of the coding portion of the APOD gene and on the cloned cDNA sequence. ![]()
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